Viral variants tend to exhibit significant sequence diversity in their envelope segment, making immunoassays solely dependent on epitopes from this region unreliable. Combining the p24 core antigen with a selected high-impact segment from the envelope would therefore make sense, and our solution is indeed patented technology:
The p24-env antigen being offered in purified, frozen format is a 256 amino acid fusion protein consisting of the type 1 HIV p24 core polypeptide with a conserved, highly immunoreactive envelope polypeptide sequence derived from HIV-1 envelope inserted at the gene level. The combined protein molecule, incorporating both core and envelope epitopes has been brought to high levels of expression enabling effective purification procedures to be implemented. The protein produces a single band on SDS and is soluble in physiological buffer. The p24-env type 1 protein does not contain any non-HIV related sequences and it has proven to be a highly effective antigen to detect anti-HIV antibodies in infected individuals.
Substantial discounts for orders exceeding 100 mg. Purchase of the protein carries an implicit license for its use as a diagnostic source ingredient.